Chronological changes in circulating levels of soluble tumor necrosis factor receptors 1 and 2 in rats with carbon tetrachloride-induced liver injury.

@article{Ijiri2014ChronologicalCI,
  title={Chronological changes in circulating levels of soluble tumor necrosis factor receptors 1 and 2 in rats with carbon tetrachloride-induced liver injury.},
  author={Yoshio Ijiri and R. Kato and Maiko Sadamatsu and Mina Takano and Yoshikatsu Okada and Kazuhiko Tanaka and Tetsuya Hayashi},
  journal={Toxicology},
  year={2014},
  volume={316},
  pages={55-60}
}
Carbon tetrachloride (CCl₄) facilitates the generation of hepatotoxins that can result in morphologic abnormalities, and these abnormalities are reasonably characteristic and reproducible for each particular toxin. It is also known that tumor necrosis factor-alpha (TNF-α) may participate in CCl₄-induced liver injury (CILI). In this study, we observed the chronological changes in circulating soluble tumor necrosis factor receptors 1 and 2 (sTNF-R1 and -R2) in rats with CILI. Laboratory data… CONTINUE READING