Chronological aging in Saccharomyces cerevisiae.

  title={Chronological aging in Saccharomyces cerevisiae.},
  author={Valter D Longo and Paola Fabrizio},
  journal={Sub-cellular biochemistry},
The two paradigms to study aging in Saccharomyces cerevisiae are the chronological life span (CLS) and the replicative life span (RLS). The chronological life span is a measure of the mean and maximum survival time of non-dividing yeast populations while the replicative life span is based on the mean and maximum number of daughter cells generated by an individual mother cell before cell division stops irreversibly. Here we review the principal discoveries associated with yeast chronological… CONTINUE READING