Chronological age affects the permeation of fentanyl through human skin in vitro.

@article{Holmgaard2013ChronologicalAA,
  title={Chronological age affects the permeation of fentanyl through human skin in vitro.},
  author={Rikke Holmgaard and Eva M Benfeldt and John A. Sorensen and Jonas B Nielsen},
  journal={Skin pharmacology and physiology},
  year={2013},
  volume={26 3},
  pages={155-9}
}
AIM To study the influence of chronological age on fentanyl permeation through human skin in vitro using static diffusion cells. Elderly individuals are known to be more sensitive to opioids and obtain higher plasma concentrations following dermal application of fentanyl compared to younger individuals. The influence of age - as an isolated pharmacokinetic term - on the absorption of fentanyl has not been previously studied. METHOD Human skin from 30 female donors was mounted in static… CONTINUE READING

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Reproduced with the permission

  • AG S.Karger, Basel
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Bagatolli LA: Storage conditions of skin affect tissue structure and subsequent in vitro percutaneous penetration

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