Chronochemotherapy of N-nitrosomethylurea-induced mammary tumors in rats. II. Circadian treatment with cyclophosphamide.

@article{PrezLpez1984ChronochemotherapyON,
  title={Chronochemotherapy of N-nitrosomethylurea-induced mammary tumors in rats. II. Circadian treatment with cyclophosphamide.},
  author={Faustino R P{\'e}rez-L{\'o}pez and Vicente Vicente Guill{\'e}n and J Hergueta and L Lafarga and M Uurcia},
  journal={Revista espanola de oncologia},
  year={1984},
  volume={31 4},
  pages={583-9}
}
The chemotherapeutic effectiveness of intraperitoneal administration of cyclophosphamide (CY) (100 mg/kg) was evaluated, on a circadian basis, on the N-nitrosomethylurea (NMU)-induced mammary tumors in female Wistar rats. Untreated rats showed a progressive increase in the mean tumor number/rat, tumor area and total tumor area/rat. The average number of… CONTINUE READING