Chrono and clinical pharmacokinetic study of tacrolimus in continuous intravenous administration.

  title={Chrono and clinical pharmacokinetic study of tacrolimus in continuous intravenous administration.},
  author={Shigeru Satoh and Harue Tada and Yuuya Tachiki and Norihiko Tsuchiya and Naotake Shimoda and Toshiya Akao and Kazunari Sato and Tomonori Habuchi and Toshio Suzuki and Tetsuro Kato},
  journal={International journal of urology : official journal of the Japanese Urological Association},
  volume={8 7},
BACKGROUND The circadian variation of clinical pharmacokinetics of tacrolimus in kidney transplant recipients receiving continuous intravenous administration has not been clarified. The aim of this study was to evaluate the circadian variation of this drug in continuous intravenous administration, with regard to the dosing scheme for conversion from intravenous to oral therapy. METHODS The blood concentration-time curve was studied in 10 living-related kidney transplant recipients, aged 18-51… CONTINUE READING


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