Chronically skipping breakfast impairs hippocampal memory-related gene expression and memory function accompanied by reduced wakefulness and body temperature in mice.

  title={Chronically skipping breakfast impairs hippocampal memory-related gene expression and memory function accompanied by reduced wakefulness and body temperature in mice.},
  author={Hiroki Okauchi and Sayaka Higo-Yamamoto and Takumi Sowa and Hideaki Oike and Saori Yamamoto and Naoyuki Wada and Katsuhiko Sakamoto and Katsutaka Oishi},
  journal={Biochemical and biophysical research communications},
Skipping Breakfast for 6 Days Delayed the Circadian Rhythm of the Body Temperature without Altering Clock Gene Expression in Human Leukocytes
Skipping breakfast for 6 days caused a phase delay in the core body temperature in healthy young men, even though the sleep–wake cycle remained unchanged, and dim light melatonin onset, heart rate variability, and clock gene expression were not affected in the 2M condition.
Stress-induced sleep-like inactivity modulates stress susceptibility in mice
Findings show that stress activates sleep-related brain regions and induces sleep-like inactivity, contributing to multiple roles of stress-induced sleep for social behaviors.
Long-Term Feeding of a High-Fat Diet Ameliorated Age-Related Phenotypes in SAMP8 Mice
The results suggest that HFD prevents aging unless metabolic disorders occur and that H FD and NtRF are independently effective in retarding aging; thus, the combination of HFD and chrono-nutritional feeding may be an effective anti-aging strategy.
Effects of time-restricted feeding and type of food on fertility competence in female mice
It is shown that mHCD feeding increases the number of ovulated oocytes and that time-restricted feeding of NC impairs the developmental competence of oocytes after fertilization, probably due to the changes in serum cholesterol levels and an increase in the ROS content in oocytes.


Midday meals do not impair mouse memory
Hippocampal memory function appears more robust to time of day and daytime feeding schedules than previously reported; day-fed mice can remember what they have seen, where they have been, and where it is dangerous.
Sleep homeostasis during daytime food entrainment in mice
This study suggests that despite substantial changes in the daily distribution and quality of wake induced by RF, sleep homeostasis is maintained, despite a similar duration of waking.
Effect of skipping breakfast for 6 days on energy metabolism and diurnal rhythm of blood glucose in young healthy Japanese males.
Sedentary lifestyle and repeated breakfast skipping caused abnormal glucose fluctuations, whereas 24-h energy metabolism remained unaffected, and there were no significant differences in 24-H energy expenditure and substrate oxidation.
Genetic disruption of the core circadian clock impairs hippocampus-dependent memory.
It is concluded that critical signaling events in the hippocampus required for memory depend on BMAL1, and that memory depends on the circadian system.
Body temperature and sleep.
  • R. Szymusiak
  • Psychology, Biology
    Handbook of clinical neurology
  • 2018
Epigenetic regulation of the circadian gene Per1 contributes to age-related changes in hippocampal memory
It is shown that epigenetic regulation of clock gene Period1 in the hippocampus regulates memory and contributes to age-related memory decline, independent of circadian rhythms.
PERIOD1 coordinates hippocampal rhythms and memory processing with daytime
The data provide a molecular blueprint for a novel role of PER1 in temporally shaping the daytime‐dependency of memory performance, likely, by gating CREB signaling, and by coupling to downstream chromatin remodeling.