Chronic zolpidem treatment alters GABA(A) receptor mRNA levels in the rat cortex.

@article{Holt1997ChronicZT,
  title={Chronic zolpidem treatment alters GABA(A) receptor mRNA levels in the rat cortex.},
  author={Richard A. Holt and Alan N. Bateson and Ian L. Martin},
  journal={European journal of pharmacology},
  year={1997},
  volume={329 2-3},
  pages={129-32}
}
The effect of chronic zolpidem treatment on the steady-state levels of gamma-aminobutyric acidA alpha1-6, beta1-3 and gamma1-3 subunit mRNAs in rat cortex has been investigated. Male Sprague-Dawley rats were injected once daily, for 7 or 14 days, with 15 mg/kg of zolpidem in sesame oil vehicle. The levels of the alpha4 and beta1 subunit mRNAs were significantly increased after 7 days of treatment and the level of alpha1 subunit mRNA was significantly decreased after 14 days of treatment, as… CONTINUE READING

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