Chronic xanthine oxidase inhibition prevents myofibrillar protein oxidation and preserves cardiac function in a transgenic mouse model of cardiomyopathy.

@article{Duncan2005ChronicXO,
  title={Chronic xanthine oxidase inhibition prevents myofibrillar protein oxidation and preserves cardiac function in a transgenic mouse model of cardiomyopathy.},
  author={Jennifer G. Duncan and Rajashree Ravi and Linda B. Stull and Anne Marie Murphy},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2005},
  volume={289 4},
  pages={H1512-8}
}
Heart failure is a clinical syndrome associated with elevated levels of oxygen-derived free radicals. Xanthine oxidase activity is believed to be one source of reactive oxygen species in the failing heart. Interventions designed to reduce oxidative stress are believed to have significant therapeutic potential in heart failure. This study tested the hypothesis that xanthine oxidase activity would be elevated in a mouse model of dilated cardiomyopathy and evaluated the effect of chronic oral… CONTINUE READING