Chronic wounds - is cellular 'reception' at fault? Examining integrins and intracellular signalling.

@article{Widgerow2013ChronicW,
  title={Chronic wounds - is cellular 'reception' at fault? Examining integrins and intracellular signalling.},
  author={Alan D Widgerow},
  journal={International wound journal},
  year={2013},
  volume={10 2},
  pages={
          185-92
        }
}
As with all physiologic processes, chronic wounds are associated with unique intracellular and cellular/extracellular matrix (ECM) receptor types and signalling messages. These cellular receptors mediate responses of the epidermis to provisional wound matrix and change in form and number in cases of impaired wound healing. Integrins are the major cell-surface receptors for cell adhesion and migration and epidermal keratinocytes express several integrins that bind ECM ligands in provisional… CONTINUE READING
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