Chronic whole-body hypoxia induces intussusceptive angiogenesis and microvascular remodeling in the mouse retina.

@article{Taylor2010ChronicWH,
  title={Chronic whole-body hypoxia induces intussusceptive angiogenesis and microvascular remodeling in the mouse retina.},
  author={Alyssa C Taylor and Lara M Seltz and Paul A. Yates and Shayn M. Peirce},
  journal={Microvascular research},
  year={2010},
  volume={79 2},
  pages={93-101}
}
Currently, little is known about the response of the adult retinal microvasculature to hypoxia. To test the hypothesis that chronic systemic hypoxia induces angiogenesis and microvascular remodeling in the adult mouse retina, adult 10-week old female C57Bl/6 mice were exposed to 10% O(2) for 2 or 3 weeks. After hypoxia exposure, retinas were harvested, whole-mounted, and processed for immunohistochemistry. Retinas were stained with lectin, anti-smooth muscle alpha-actin antibody, and anti-NG2… CONTINUE READING