Chronic valproate attenuates some, but not all, facets of mania-like behaviour in mice.

@article{Enkhuizen2013ChronicVA,
  title={Chronic valproate attenuates some, but not all, facets of mania-like behaviour in mice.},
  author={Jordy van Enkhuizen and Mark A. Geyer and Klaas Kooistra and Jared W. Young},
  journal={The international journal of neuropsychopharmacology},
  year={2013},
  volume={16 5},
  pages={1021-31}
}
Bipolar disorder (BD) mania is a psychiatric disorder with multifaceted symptoms. Development of targeted treatments for BD mania may benefit from animal models that mimic multiple symptoms, as opposed to hyperactivity alone. Using the reverse-translated multivariate exploratory paradigm, the behavioural pattern monitor (BPM), we reported that patients with BD mania exhibit hyperactivity as well as increased specific exploration and more linear movements through space. This abnormal profile is… CONTINUE READING
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