Chronic vagal stimulation for the treatment of low ejection fraction heart failure: results of the NEural Cardiac TherApy foR Heart Failure (NECTAR-HF) randomized controlled trial

@inproceedings{Zannad2015ChronicVS,
  title={Chronic vagal stimulation for the treatment of low ejection fraction heart failure: results of the NEural Cardiac TherApy foR Heart Failure (NECTAR-HF) randomized controlled trial},
  author={Fa{\"i}ez Zannad and Gaetano M. De Ferrari and Anton E. Tuinenburg and David J Wright and Josep Brugada and Christian Butter and Helmut U. Klein and Craig M Stolen and Scott Meyer and Kenneth M. Stein and Agn{\`e}s Ramuzat and Bernd Schubert and Doug Daum and Petr Neu{\vz}il and Cornelis J Botman and Mar{\'i}a {\'A}ngeles Castel and Antonio D'Onofrio and Scott Solomon and Nicholas David Wold and Stephen B. Ruble},
  booktitle={European heart journal},
  year={2015}
}
AIM The neural cardiac therapy for heart failure (NECTAR-HF) was a randomized sham-controlled trial designed to evaluate whether a single dose of vagal nerve stimulation (VNS) would attenuate cardiac remodelling, improve cardiac function and increase exercise capacity in symptomatic heart failure patients with severe left ventricular (LV) systolic dysfunction despite guideline recommended medical therapy. METHODS Patients were randomized in a 2 : 1 ratio to receive therapy (VNS ON) or control… CONTINUE READING

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