Chronic unpredictable stress promotes neuronal apoptosis in the cerebral cortex.

  title={Chronic unpredictable stress promotes neuronal apoptosis in the cerebral cortex.},
  author={Alessia Bachis and Maria Idalia Cruz and Rachel L. Nosheny and Italo Mocchetti},
  journal={Neuroscience letters},
  volume={442 2},
Stress-mediated loss of synaptogenesis in the hippocampus appears to play a role in depressive and mood disorders. However, little is known about the effect of stress/depression on the plasticity and survival of cortical neurons. In this report, we have examined whether chronic stress increases the vulnerability of neurons in the rat cortex. We have used a chronic unpredictable mild stress (CMS) as a rat model of depression. CMS (5 weeks treatment) produced anedonia and increased corticosterone… CONTINUE READING

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