Chronic unloading by left ventricular assist device reverses contractile dysfunction and alters gene expression in end-stage heart failure.


BACKGROUND Left ventricular (LV) assist devices (LVADs) can improve contractile strength and normalize characteristics of the Ca(2+) transient in myocytes isolated from failing human hearts. The purpose of the present study was to determine whether LVAD support also improves contractile strength at different frequencies of contraction (the force-frequency… (More)


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