Chronic tumor necrosis factor-alpha treatment causes insulin resistance via insulin receptor substrate-1 serine phosphorylation and suppressor of cytokine signaling-3 induction in 3T3-L1 adipocytes.

@article{Ishizuka2007ChronicTN,
  title={Chronic tumor necrosis factor-alpha treatment causes insulin resistance via insulin receptor substrate-1 serine phosphorylation and suppressor of cytokine signaling-3 induction in 3T3-L1 adipocytes.},
  author={Ken Ishizuka and Isao Usui and Yukiko Kanatani and Agussalim Bukhari and Jianying He and Shiho Fujisaka and Yu Yamazaki and Hikari Suzuki and Kazuyuki Hiratani and Manabu Ishiki and Minoru Iwata and Masaharu Urakaze and Tetsuro Haruta and Masashi Kobayashi},
  journal={Endocrinology},
  year={2007},
  volume={148 6},
  pages={2994-3003}
}
Serine phosphorylation of insulin receptor substrate (IRS)-1 and the induction of suppressor of cytokine signaling 3 (SOCS3) is recently well documented as the mechanisms for the insulin resistance. However, the relationship between these two mechanisms is not fully understood. In this study, we investigated the involvement of SOCS3 and IRS-1 serine phosphorylation in TNFalpha-induced insulin resistance in 3T3-L1 adipocytes. TNFalpha transiently stimulated serine phosphorylation of IRS-1 from… CONTINUE READING