Chronic treatment with tetrahydrobiopterin reverses endothelial dysfunction and oxidative stress in hypercholesterolaemia.

@article{Cosentino2008ChronicTW,
  title={Chronic treatment with tetrahydrobiopterin reverses endothelial dysfunction and oxidative stress in hypercholesterolaemia.},
  author={Francesco Cosentino and David Huerlimann and Chiara delli Gatti and R{\'e}my Chenevard and Nenad Blau and Nicholas J. Alp and Keith M. Channon and Masato Eto and Peter Lerch and Frank Enseleit and Frank T. Ruschitzka and Massimo Volpe and Thomas Felix L{\"u}scher and Georg Noll},
  journal={Heart},
  year={2008},
  volume={94 4},
  pages={487-92}
}
BACKGROUND Reduced availability of tetrahydrobiopterin (BH(4)), an essential cofactor of nitric oxide (NO) synthase (NOS), decreases NO production and increases reactive oxygen species. Both mechanisms contribute to atherosclerotic vascular disease. Although acute supplementation of BH(4) improves endothelial dysfunction, the effect of chronic BH(4) in humans is unknown. OBJECTIVE To investigate the effect of chronic BH(4) supplementation on endothelial function and oxidative stress in… CONTINUE READING

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