Chronic treatment with simvastatin upregulates muscarinic M1/4 receptor binding in the rat brain

@article{Wang2008ChronicTW,
  title={Chronic treatment with simvastatin upregulates muscarinic M1/4 receptor binding in the rat brain},
  author={Q. Wang and A. Zengin and W. Ying and K. Newell and X. F. Huang},
  journal={Neuroscience},
  year={2008},
  volume={154},
  pages={1100-1106}
}
Statins are increasingly being used for the treatment of a variety of conditions beyond their original indication for cholesterol lowering. We previously reported that simvastatin affected the dopaminergic system in the rat brain. This study aims to investigate regional changes of muscarinic M1/4 receptors in the rat brain after 4-week administration of simvastatin (1 or 10 mg/kg/day). M1/4 receptor distribution and alterations in the post-mortem rat brain were detected by [(3)H]pirenzepine… Expand
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