Chronic treatment with finasteride daily does not affect spermatogenesis or semen production in young men.

@article{Overstreet1999ChronicTW,
  title={Chronic treatment with finasteride daily does not affect spermatogenesis or semen production in young men.},
  author={James W. Overstreet and Vincent L Fuh and Jayne Gould and Stuart S. Howards and Michael M. Lieber and Wayne J G Hellstrom and Samuel Shapiro and Peter Carroll and R S Corfman and Stavros Petrou and Richard Lewis and P T{\'o}th and T Shown and Johnny B Roy and Jonathan P. Jarow and J. F. Jim{\'e}nez Bonilla and Craig A. Jacobsen and Daniel Z Wang and Keith D. Kaufman},
  journal={The Journal of urology},
  year={1999},
  volume={162 4},
  pages={1295-300}
}
PURPOSE Finasteride, an oral type 2, 5alpha-reductase inhibitor, is used in 1 mg. daily doses for the treatment of male pattern hair loss. A dose of 5 mg. finasteride daily reduces ejaculate volume by approximately 25%, and reduces prostate volume by approximately 20% and serum prostate specific antigen (PSA) by approximately 50% in men with benign prostatic hyperplasia. To our knowledge no data exist on the effect of 1 mg. finasteride daily on ejaculate volume or other semen parameters, or on… CONTINUE READING

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Prostate-Specific AntigenGene product expressed in tissueProstate
finasteride daily reduces ejaculate volume by approximately 25% , and reduces prostate volume by approximately 20% and serum prostate specific antigen ( PSA ) by approximately 50% in men with benign prostatic hyperplasia .
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