Chronic treatment with dizocilpine maleate increases the number of striatal neurons expressing the D2 receptor gene.

@article{Lannes1995ChronicTW,
  title={Chronic treatment with dizocilpine maleate increases the number of striatal neurons expressing the D2 receptor gene.},
  author={B{\'e}atrice Lannes and V{\'e}ronique Bernard and Bertrand Bloch and Giancarlo Micheletti},
  journal={Neuroscience},
  year={1995},
  volume={65 2},
  pages={431-8}
}
N-methyl-D-aspartate antagonists have been proposed as potential therapeutic agents in different neurological diseases, including Parkinson's disease. The effects of gene expression of a chronic treatment with the non-competitive N-methyl-D-aspartate antagonist, dizocilpine maleate (0.8 mg/kg day, per os for 50 days) were analysed in rat striata. Using quantitative in situ hybridization, we measured the messenger RNA expression of the genes encoding D1, D2 dopamine receptors, N-methyl-D… CONTINUE READING

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