Chronic treatment with clozapine, unlike haloperidol, does not induce changes in striatal D-2 receptor function in the rat.

@article{Rupniak1985ChronicTW,
  title={Chronic treatment with clozapine, unlike haloperidol, does not induce changes in striatal D-2 receptor function in the rat.},
  author={Nadia M. J. Rupniak and Matthew D. Hall and Stephen P. Mann and Simon Fleminger and G J Kilpatrick and P Feroz Jenner and C. David Marsden},
  journal={Biochemical pharmacology},
  year={1985},
  volume={34 15},
  pages={2755-63}
}
Comparison has been made of the effects on brain dopamine function of chronic administration of haloperidol or clozapine to rats for up to 12 months. In rats treated for 1-12 months with haloperidol (1.4-1.6 mg/kg/day), purposeless chewing jaw movements emerged. These movements were only observed after 12 months' treatment with clozapine (24-27 mg/kg/day). Apomorphine-induced (0.125-0.25 mg/kg) stereotyped behaviour was inhibited during 12 months treatment with haloperidol. Clozapine treatment… CONTINUE READING