Chronic treatment with antidepressants: Potentiation of clonidine-induced aggression in mice via noradrenergic mechanism

@article{Maj1981ChronicTW,
  title={Chronic treatment with antidepressants: Potentiation of clonidine-induced aggression in mice via noradrenergic mechanism},
  author={Jerzy Maj and Ewa Mogilnicka and Violetta Klimek and Anna Kordecka-Magiera},
  journal={Journal of Neural Transmission},
  year={1981},
  volume={52},
  pages={189-197}
}
The chronic (10mg/kg i.p. twice daily, 10 days)-and not the acute-administration of amitriptyline, maprotiline or zimelidine enhances aggressiveness induced by clonidine in mice. An analogous potentiation of clonidine-induced aggressiveness was obtained with chronic administration (the schedule as above) of levomepromazine (2 mg/kg) or thioridazine (5 mg/kg) but not of spiperone (0.2 mg/kg). Fluoxetine (10 mg/kg), atropine (5 mg/kg), propranolol (10 mg/kg) or metergoline (0.5 mg/kg) given… CONTINUE READING

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: Effect of chronic administration of antidepressant drugs on aggressive behaviour induced by clonidine in mice

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