Chronic treatment with a synthetic cannabinoid CP-55,940 alters G-protein expression in the rat central nervous system.

@article{Rubino1997ChronicTW,
  title={Chronic treatment with a synthetic cannabinoid CP-55,940 alters G-protein expression in the rat central nervous system.},
  author={T. Rubino and G. Patrini and M. Parenti and P. Massi and D. Parolaro},
  journal={Brain research. Molecular brain research},
  year={1997},
  volume={44 2},
  pages={
          191-7
        }
}
Prolonged exposure of rats to the synthetic cannabinoid receptor ligand, CP-55,940 (0.4 mg/kg, i.p. for 11 days), induced tolerance to analgesia, to the reduction in spontaneous locomotor activity and the incidence of splayed hind limbs. One hour after the last injection on day 11, the rats were killed and in situ hybridization was used to investigate the effect of treatment on G-protein alpha-subunit expression throughout the brain. Chronic cannabinoid exposure markedly reduced G alpha(s), G… Expand
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