Chronic treatment with Ro 15-1788 distinguishes between its benzodiazepine antagonist, agonist and inverse agonist properties

@article{File1986ChronicTW,
  title={Chronic treatment with Ro 15-1788 distinguishes between its benzodiazepine antagonist, agonist and inverse agonist properties},
  author={Sandra E. File and Jasper Dingemanse and Hylar L Friedman and David J Greenblatt},
  journal={Psychopharmacology},
  year={1986},
  volume={89},
  pages={113-117}
}
Ro 15-1788 (flumazepil) is an imidazodiazepine that is able to antagonise most of the behavioural actions of the benzodiazepines, as well as having some intrinsic effects. Acute administration of Ro 15-1788 (10 mg/kg) decreases social interaction between male rats and elevates exploratory head-dipping. After 5 days of pretreatment there was tolerance to the former effect, although Ro 15-1788 retained its ability to antagonise the effects on social interaction of the β-carboline, FG 7142. Ro 15… CONTINUE READING

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