Chronic treatment with N‐acetylcysteine decreases extinction responding and reduces cue‐induced nicotine‐seeking

@inproceedings{Powell2019ChronicTW,
  title={Chronic treatment with N‐acetylcysteine decreases extinction responding and reduces cue‐induced nicotine‐seeking},
  author={Gregory L. Powell and Jonna M. Leyrer‐Jackson and Julianna Gloria Goenaga and Mark D Namba and Jos{\'e} Pina and Sade M Spencer and Neringa M Stankeviciute and Danielle J. Schwartz and Nicholas P Allen and Armani P. Del Franco and Erin A McClure and M Foster Olive and Cassandra D Gipson},
  booktitle={Physiological reports},
  year={2019}
}
N-acetylcysteine (NAC), a promising glutamatergic therapeutic agent, has shown some clinical efficacy in reducing nicotine use in humans and has been shown to reverse drug-induced changes in glutamatergic neurophysiology. In rats, nicotine-seeking behavior is associated with alterations in glutamatergic plasticity within the nucleus accumbens core (NAcore). Specifically, cue-induced nicotine-seeking is associated with rapid, transient synaptic plasticity (t-SP) in glutamatergic synapses on… CONTINUE READING

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