Chronic treatment of mitochondrial disease patients with dichloroacetate.

  title={Chronic treatment of mitochondrial disease patients with dichloroacetate.},
  author={Bruce A Barshop and Robert K. Naviaux and Karen A McGowan and Fred Levine and William L. Nyhan and Amalia Loupis-Geller and Richard H. Haas},
  journal={Molecular genetics and metabolism},
  volume={83 1-2},
Clinical features are reported for 37 patients with various mitochondrial disorders, treated with sodium dichloroacetate (DCA) for 3 weeks to 7 years (mean 3.25 years) at 11-50 mg/kg/day (34.6+/-13.1) in an open-label format. DCA pharmacokinetics showed half-times approximately 86 min for the first intravenous dose of 50 mg/kg, 3.2 h for a subsequent intravenous dose 4-6 h later, and 11 h after continued oral dosing of 12.5-25 mg/kg twice daily. Basal blood and CSF lactate (mean values at entry… CONTINUE READING
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