Chronic treatment and withdrawal of the cannabinoid agonist WIN 55,212-2 modulate the sensitivity of presynaptic receptors involved in the regulation of monoamine syntheses in rat brain

@article{Moranta2008ChronicTA,
  title={Chronic treatment and withdrawal of the cannabinoid agonist WIN 55,212-2 modulate the sensitivity of presynaptic receptors involved in the regulation of monoamine syntheses in rat brain},
  author={D Moranta and Susana Esteban and Jes{\'u}s Andr{\'e}s Garc{\'i}a-Sevilla},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2008},
  volume={379},
  pages={61-72}
}
Brain monoamines are involved in many neurochemical and behavioral effects of cannabinoids, but little is known on the regulation of noradrenaline, dopamine, and serotonin (5-HT) synthesis in cannabinoid addiction. This study investigated in rat brain the chronic effects of the potent cannabinoid agonist WIN 55,212-2 and of rimonabant-precipitated withdrawal, as well as the sensitivity of synthesis-modulating inhibitory receptors, on the accumulation of l-3,4-dihydroxyphenylalanine (DOPA) and 5… CONTINUE READING
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α2adrenoceptor subtypes. Naunyn-Schmiedeberg’s Arch Pharmacol

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