Chronic traumatic encephalopathy in sport: a systematic review

@article{Gardner2013ChronicTE,
  title={Chronic traumatic encephalopathy in sport: a systematic review},
  author={Andrew J. Gardner and Grant L. Iverson and Paul McCrory},
  journal={British Journal of Sports Medicine},
  year={2013},
  volume={48},
  pages={84 - 90}
}
Objective To provide a critical review of chronic traumatic encephalopathy (CTE) by considering the range of clinical presentations, neuropathology and the strength of evidence for CTE as a distinct syndrome. Data sources Seven electronic databases were searched using a combination of MeSH terms and key words to identify relevant articles. Review methods Specific inclusion and exclusion criteria were used to select studies for review. Data extracted where present included study population… 
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172 Citations
Highly Influential Citations
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Background Citations
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Methods Citations
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Results Citations
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172 Citations

Chronic Traumatic Encephalopathy in Contact Sports: A Systematic Review of All Reported Pathological Cases

It is found that a history of mTBI was the only risk factor consistently associated with CTE, and no relationships between CTE and age of death or abnormal ApoE allele were found, and the incidence of CTE remains unknown due to the lack of large, longitudinal studies.

A Clinical Approach to the Diagnosis of Traumatic Encephalopathy Syndrome: A Review.

This clinical paradigm will provide the framework for a diagnosis of probable, possible, and unlikely traumatic encephalopathy syndrome, with included discussion regarding the minimum exposure, nature of the clinical course, and additional clinical features needed for diagnosis.

Chronic Traumatic Encephalopathy (CTE)

This chapter will review the posited pathology and emerging clinical presentation of CTE, with discussion of limitations of both and a clinical approach to management in patients where CTE is suspected is outlined.

The Current Status of Research on Chronic Traumatic Encephalopathy.

Chronic Traumatic Encephalopathy and Traumatic Brain Injury: Bridging Pathology, Function, and Prognosis

The aim of this review is to analyze the current literature on CTE, to juxtapose CTE literature with the more abundant research on mild traumatic brain injury (mTBI), and to offer recommendations for clinicians working with at-risk patients.

Chronic traumatic encephalopathy: How serious a sports problem is it?

It is now recognised that there is a spectrum of concussion disorders ranging from acute concussion at one end to various forms of brain degeneration at the other end, which includes chronic traumatic encephalopathy (CTE), and it is essential to carefully evaluate the clinical and neuropathological correlations of CTE that have been published.

Chronic traumatic encephalopathy: clinical presentation and in vivo diagnosis.

Factors Influencing Clinical Correlates of Chronic Traumatic Encephalopathy (CTE): a Review

Cognitive, emotional, and behavioral changes associated with developmental and demographic factors, and neurodevelopmental disorders should be considered as modifiers predominantly of the clinical outcomes associated with repetitive brain trauma within a broader biopsychosocial framework, though also note potential effects on neuropathological outcomes.

The Neuropathological and Clinical Diagnostic Criteria of Chronic Traumatic Encephalopathy: A Critical Examination in Relation to Other Neurodegenerative Diseases.

CTE is compared to other well-established neurodegenerative entities including Alzheimer's disease and dementia with Lewy bodies and indicates that CTE is a disease in the earliest stages of formation and has yet to undergo rigorous development and refinement similar to other neurodegenersative diseases.

Research Gaps and Controversies in Chronic Traumatic Encephalopathy: A Review

It is indicated that exposure to RBT represents the greatest risk factor for CTE pathological features, although clinicopathological correlates and the nature of onset and progression of symptoms are largely unknown.
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