Chronic traumatic encephalopathy: neurodegeneration following repetitive concussive and subconcussive brain trauma
@article{Baugh2012ChronicTE, title={Chronic traumatic encephalopathy: neurodegeneration following repetitive concussive and subconcussive brain trauma}, author={Christine M Baugh and Julie M. Stamm and David O. Riley and Brandon E. Gavett and Martha Elizabeth Shenton and Alexander P Lin and Christopher J. Nowinski and Robert C. Cantu and Ann C. McKee and Robert A. Stern}, journal={Brain Imaging and Behavior}, year={2012}, volume={6}, pages={244-254} }
Chronic Traumatic Encephalopathy (CTE) is a neurodegenerative disease thought to be caused, at least in part, by repetitive brain trauma, including concussive and subconcussive injuries. It is thought to result in executive dysfunction, memory impairment, depression and suicidality, apathy, poor impulse control, and eventually dementia. Beyond repetitive brain trauma, the risk factors for CTE remain unknown. CTE is neuropathologically characterized by aggregation and accumulation of…
412 Citations
Chronic Traumatic Encephalopathy
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The condition shares some molecular pathologies with other neurodegenerative disorders and it appears that repetitive concussion can initiate a degenerative process involving protein misfolding that may propagate over the brain many years after the trauma.
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Sports-related concussion has gained increased prominence, in part due to media coverage of several well-known athletes who have died from consequences of chronic traumatic encephalopathy (CTE). CTE…
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Future programs, such as Return to Play (RTP) guidelines, must more effectively prevent and treat concussions in professional athletes, and especially in youth athletes.
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Positron emission tomography scans with radioactive ligands such as T807 as an imaging biomarker, and neurofilament light and ubiquitin C‐terminal hydrolase as serum biomarkers have shown some promise lately in diagnosing concussion and chronic traumatic encephalopathy and also determining their prognosis.
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