Chronic toxicity of styrene maleic anhydride, a male contraceptive, in rhesus monkeys (Macaca mulatta).

@article{Sethi1990ChronicTO,
  title={Chronic toxicity of styrene maleic anhydride, a male contraceptive, in rhesus monkeys (Macaca mulatta).},
  author={Nitin Sethi and Rajiv Kumar Srivastava and Rahul Kumar S.K. Singh and Galub Bhatia and Neil Sinha},
  journal={Contraception},
  year={1990},
  volume={42 3},
  pages={
          337-47
        }
}
A newly developed male contraceptive, styrene maleic anhydride (SMA), was injected in the vas deferens of male rhesus monkeys for safety evaluation at the dose of 100 mg (contraceptive dose, CD), 250 mg (CD x 2.5) and 500 mg (CD x 5.0), and the monkeys were kept under observation for one year. The observed behavioural, haematological, biochemical and histopathological parameters in treated monkeys were comparable to controls. The results suggest the polymer SMA to be safe up to 5 times CD in… CONTINUE READING
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