Chronic toxic encephalopathy caused by occupational solvent exposure

  title={Chronic toxic encephalopathy caused by occupational solvent exposure},
  author={Edward L. Baker},
  journal={Annals of Neurology},
  • E. Baker
  • Published 1 May 2008
  • Biology
  • Annals of Neurology
References 1. Carpenter S, Karpati G. Pathology of skeletal muscle. 2nd ed. New York: Oxford University Press, 2001. 2. Patel K, Muntoni F. Inducing muscle hypertrophy as a therapeutic strategy for muscular dystrophies. 122nd ENMC International Workshop, Naarden, The Netherlands, 28-30 November 2003. Neuromuscul Disord 2004;14:519–525. 3. Patel K, Amthor H. The function of myostatin and strategies of myostatin blockade—new hope for therapies aimed at promoting growth of skeletal muscle… 
4 Citations
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Neurocognitieve stoornissen


The Effects of Toluene on the Central Nervous System
The impact of toluene abuse on the authors' society is considered, the specific neurobehavioral deficits in toluenes leukoencephalopathy are described, the spectrum of neuroimaging findings in patients with this disorder are reviewed, the teratogenic effects of toLUene in both humans and animal models are summarized, and possible explanations for the range of neuropathological damage seen in brains of individuals who chronically abuse toluen are offered.
Do organic solvents induce changes in the dopaminergic system? Positron emission tomography studies of occupationally exposed subjects
The hypothesis that long-term exposure to organic solvents may increase the rate of dopamine synthesis in the brain without affecting the number of presynaptic terminals or postsynaptic dopamine receptors is supported.
Neurotoxic effects of organic solvents in exposed workers: two controlled follow-up studies after 5.5 and 10.6 years.
  • P. Gregersen
  • Psychology, Medicine
    American journal of industrial medicine
  • 1988
According to the findings, long-term occupational exposure to organic solvents in concentrations that are not unusual at workplaces may lead to development of chronic neurotoxic symptoms.
Three-dimensional brain metabolic imaging in patients with toxic encephalopathy.
This series of patients adds to the previous experience of brain metabolic imaging and demonstrates that certain areas of the brain are typically affected despite differences in toxin structure, that these lesions can be globally defined by SPECT/PET brain scans, and that such testing is a useful adjunct to previous methods.
White matter changes caused by chronic solvent abuse.
There are some patients with restricted but severe enough change to cause the neurologic symptoms in specific regions, such as the brain stem and/or cerebellum, before the brain atrophy becomes apparent, which suggests that the restricted white matter change represents not only an early change of diffuseWhite matter change, but at least in some cases also represents a qualitatively different change than that of diffusewhite matter change.
A review of recent research on health effects of human occupational exposure to organic solvents. A critical review.
  • E. Baker
  • Medicine
    Journal of occupational medicine. : official publication of the Industrial Medical Association
  • 1994
In this review of research performed since 1985, particular attention is given to issues of reversibility of neurotoxicity following exposure cessation and health effects involving other organ systems, particularly reproductive, renal, and hepatic disorders.
Regulation of myostatin activity and muscle growth
  • Se-Jin Lee, A. Mcpherron
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 2001
The findings suggest that the propeptide, follistatin, or other molecules that block signaling through this pathway may be useful agents for enhancing muscle growth for both human therapeutic and agricultural applications.
Solvents and neurotoxicity
Risk Factors Associated with Persistence of Neuropsychological Deficits in Persons with Organic Solvent Exposure
Results from this study suggest that the presence of certain risk factors, namely a peak exposure and psychological distress, may be particularly detrimental for long-term neuropsychological outcome in persons with a history of organic solvent exposure.