Chronic systemic injection of D-galactose impairs the septohippocampal cholinergic system in rats.

@article{Lei2008ChronicSI,
  title={Chronic systemic injection of D-galactose impairs the septohippocampal cholinergic system in rats.},
  author={Ming Lei and Yang Su and Xiangdong Hua and Jiong Ding and Qunying Han and Gang Hu and Ming Xiao},
  journal={Neuroreport},
  year={2008},
  volume={19 16},
  pages={1611-5}
}
Accumulated evidence indicates chronic systemic injection of D-galactose mimics aging progress induced by oxidative stress. We addressed whether memory impairment in this model was associated with the cholinergic septohippocampal degeneration. Rats injected with D-galactose for 6 weeks showed impairment of spatial learning and memory as measured by the water maze test. Correspondingly, anti-choline acetyltransferase immunohistochemistry demonstrated a severe loss of cholinergic terminals in the… CONTINUE READING

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