Chronic systemic complex I inhibition induces a hypokinetic multisystem degeneration in rats.

@article{Hglinger2003ChronicSC,
  title={Chronic systemic complex I inhibition induces a hypokinetic multisystem degeneration in rats.},
  author={G{\"u}nter U. H{\"o}glinger and Jean F{\'e}ger and Annick Prigent and Patrick P Michel and K. Parain and Pierre Champy and Merle Ruberg and Wolfgang Hermann Oertel and Etienne C. Hirsch},
  journal={Journal of neurochemistry},
  year={2003},
  volume={84 3},
  pages={491-502}
}
In Parkinson's disease, nigral dopaminergic neurones degenerate, whereas post-synaptic striatal target neurones are spared. In some atypical parkinsonian syndromes, both nigral and striatal neurones degenerate. Reduced activity of complex I of the mitochondrial respiratory chain has been implicated in both conditions, but it remains unclear if this affects the whole organism or only the degenerating brain structures. We therefore investigated the differential vulnerability of various brain… CONTINUE READING