Chronic systemic D‐galactose exposure induces memory loss, neurodegeneration, and oxidative damage in mice: Protective effects of R‐α‐lipoic acid

  title={Chronic systemic D‐galactose exposure induces memory loss, neurodegeneration, and oxidative damage in mice: Protective effects of R‐α‐lipoic acid},
  author={X. Cui and P. Zuo and Q. Zhang and Xuekun Li and Ya-zhuo Hu and J. Long and L. Packer and J. Liu},
  journal={Journal of Neuroscience Research},
  • X. Cui, P. Zuo, +5 authors J. Liu
  • Published 2006
  • Medicine
  • Journal of Neuroscience Research
  • Chronic systemic exposure of mice, rats, and Drosophila to D‐galactose causes the acceleration of senescence and has been used as an aging model. The underlying mechanism is yet unclear. To investigate the mechanisms of neurodegeneration in this model, we studied cognitive function, hippocampal neuronal apoptosis and neurogenesis, and peripheral oxidative stress biomarkers, and also the protective effects of the antioxidant R‐alpha‐lipoic acid. Chronic systemic exposure of D‐galactose (100 mg… CONTINUE READING
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