Chronic synovitis with early cartilage destruction in sickle cell disease.

@article{Schumacher1977ChronicSW,
  title={Chronic synovitis with early cartilage destruction in sickle cell disease.},
  author={Harold R. Schumacher and B B Dorwart and Jacquelyn Bond and Abass Alavi and Wallace Miller},
  journal={Annals of the rheumatic diseases},
  year={1977},
  volume={36 5},
  pages={413-9}
}
Two patients with sickle cell disease presented with joint pain and early x-ray evidence of articular cartilage loss. Both later developed increasingly destructive arthritis with chronic synovitis identified in synovial biopsies. One patient developed demonstrable aseptic necrosis. Destructive arthropathy is much less common than the frequent transient effusions in sickle cell disease. 

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Hydroxyapatite - like crystals in synovial fluid cell vacuoles

H. R. Schumacher, R. Tse, A. J. Reginato, J. Miller, K. Maurer
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