Chronic supplementation of creatine and vitamins C and E increases survival and improves biochemical parameters after Doxorubicin treatment in rats.

@article{Santos2007ChronicSO,
  title={Chronic supplementation of creatine and vitamins C and E increases survival and improves biochemical parameters after Doxorubicin treatment in rats.},
  author={Ronaldo Vagner Thomatieli Santos and Miguel Lu{\'i}s Batista and Erico Chagas Caperuto and Luis Fbp Costa Rosa},
  journal={Clinical and experimental pharmacology & physiology},
  year={2007},
  volume={34 12},
  pages={
          1294-9
        }
}
1. Doxorubicin is an anti-cancer drug with well-described effects against a wide range of tumours. However, doxorubicin also exhibits dose-dependent cytotoxicity. The purpose of the present study was to determine whether chronic supplementation of creatine or a mix of vitamins C and E could increase survival and improve plasma parameters 48 h after doxorubicin treatment. 2. Rats were divided into four groups: (i) saline (control); (ii) doxorubicin treated; (iii) a creatine (0.2 g/kg per day… CONTINUE READING
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