Chronic subhepatotoxic exposure to arsenic enhances hepatic injury caused by high fat diet in mice.

@article{Tan2011ChronicSE,
  title={Chronic subhepatotoxic exposure to arsenic enhances hepatic injury caused by high fat diet in mice.},
  author={Min Tan and Robin H. Schmidt and Juliane I Beier and Walter H. Watson and Hai Zhong and J Christopher States and Gavin E. Arteel},
  journal={Toxicology and applied pharmacology},
  year={2011},
  volume={257 3},
  pages={356-64}
}
Arsenic is a ubiquitous contaminant in drinking water. Whereas arsenic can be directly hepatotoxic, the concentrations/doses required are generally higher than present in the US water supply. However, physiological/biochemical changes that are alone pathologically inert can enhance the hepatotoxic response to a subsequent stimulus. Such a '2-hit' paradigm is best exemplified in chronic fatty liver diseases. Here, the hypothesis that low arsenic exposure sensitizes liver to hepatotoxicity in a… CONTINUE READING

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