Chronic stress reduces the number of GABAergic interneurons in the adult rat hippocampus, dorsal-ventral and region-specific differences.

@article{Czh2015ChronicSR,
  title={Chronic stress reduces the number of GABAergic interneurons in the adult rat hippocampus, dorsal-ventral and region-specific differences.},
  author={Boldizs{\'a}r Cz{\'e}h and Zs{\'o}fia K Kalangy{\'a}n{\'e} Varga and Kim Henningsen and G{\'a}bor L{\'a}szl{\'o} Kov{\'a}cs and Attila Miseta and Ove Wiborg},
  journal={Hippocampus},
  year={2015},
  volume={25 3},
  pages={393-405}
}
Major depressive disorder is a common and complex mental disorder with unknown etiology. GABAergic dysfunction is likely to contribute to the pathophysiology since disrupted GABAergic systems are well documented in depressed patients. Here we studied structural changes in the hippocampal GABAergic network using the chronic mild stress (CMS) model, as one of the best validated animal models for depression. Rats were subjected to 9 weeks of daily stress and behaviorally characterized using the… CONTINUE READING
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