Chronic stress promotes the progression of pressure overload-induced cardiac dysfunction through inducing more apoptosis and fibrosis.

  title={Chronic stress promotes the progression of pressure overload-induced cardiac dysfunction through inducing more apoptosis and fibrosis.},
  author={W. Liu and X. Wang and Z. Mei and J. Gong and X. Gao and Y. Zhao and J. Ma and F. Xie and L. Qian},
  journal={Physiological research},
  volume={64 3},
  • W. Liu, X. Wang, +6 authors L. Qian
  • Published 2015
  • Medicine
  • Physiological research
  • Stress serves as a risk factor in the etiology of hypertension. The present study was designed to decipher the effect and mechanism of chronic stress on the progression of pressure overload-induced cardiac dysfunction. We used abdominal aortic constriction (AAC) to induce pressure overload with or without chronic restraint stress to establish the animal models. Echocardiographic analysis showed pressure overload-induced cardiac dysfunction was worsened by chronic stress. Compared with the AAC… CONTINUE READING
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