Chronic stress promotes the progression of pressure overload-induced cardiac dysfunction through inducing more apoptosis and fibrosis.

@article{Liu2015ChronicSP,
  title={Chronic stress promotes the progression of pressure overload-induced cardiac dysfunction through inducing more apoptosis and fibrosis.},
  author={W. Liu and X. Wang and Z. Mei and J. Gong and X. Gao and Y. Zhao and J. Ma and F. Xie and L. Qian},
  journal={Physiological research},
  year={2015},
  volume={64 3},
  pages={
          325-34
        }
}
  • W. Liu, X. Wang, +6 authors L. Qian
  • Published 2015
  • Medicine
  • Physiological research
  • Stress serves as a risk factor in the etiology of hypertension. The present study was designed to decipher the effect and mechanism of chronic stress on the progression of pressure overload-induced cardiac dysfunction. We used abdominal aortic constriction (AAC) to induce pressure overload with or without chronic restraint stress to establish the animal models. Echocardiographic analysis showed pressure overload-induced cardiac dysfunction was worsened by chronic stress. Compared with the AAC… CONTINUE READING
    13 Citations

    Figures and Topics from this paper

    The pretreatment of chronic restraint stress exerts little impact on the progression of heart failure in mice
    • 1
    Crosstalk between GSK-3β-actuated molecular cascades and myocardial physiology
    • 1
    Chronic stress impairs male spermatogenesis function and Nectin-3 protein expression in the testis.
    • 1
    Mitochondrial Ubiquitin Ligase in Cardiovascular Disorders.
    • 2

    References

    SHOWING 1-10 OF 41 REFERENCES
    Regulation of Cardiac Remodeling by Nitric Oxide: Focus on Cardiac Myocyte Hypertrophy and Apoptosis
    • 96
    Hsp70 may protect cardiomyocytes from stress-induced injury by inhibiting Fas-mediated apoptosis
    • 59
    Alpha-calcitonin gene-related peptide is protective against pressure overload-induced heart failure
    • 32
    Effect of a high-protein diet on development of heart failure in response to pressure overload.
    • 14
    A Juvenile Murine Heart Failure Model of Pressure Overload
    • 2
    Remodeling of the rat right and left ventricles in experimental hypertension.
    • 694
    • PDF
    Novel Strategies for the Treatment of Heart Failure
    • I. Kehat
    • Medicine
    • Rambam Maimonides medical journal
    • 2012
    • 3
    • PDF
    Stress and Obesity as Risk Factors in Cardiovascular Diseases: A Neuroimmune Perspective
    • 41
    The cardiac fibroblast: therapeutic target in myocardial remodeling and failure.
    • 594
    The Role of Sulfur Dioxide in the Regulation of Mitochondrion-Related Cardiomyocyte Apoptosis in Rats with Isopropylarterenol-Induced Myocardial Injury
    • 41
    • PDF