Chronic stress induces impairment of spatial working memory because of prefrontal dopaminergic dysfunction.

@article{Mizoguchi2000ChronicSI,
  title={Chronic stress induces impairment of spatial working memory because of prefrontal dopaminergic dysfunction.},
  author={Kazushige Mizoguchi and Mitsutoshi Yuzurihara and Atsushi Ishige and Hiroshi Sasaki and De Hua Chui and Takeshi Tabira},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2000},
  volume={20 4},
  pages={1568-74}
}
Although the mechanism responsible for cognitive deficits in stress-related neuropsychiatric disorders has been obscure, prefrontal cortical (PFC) dopaminergic dysfunction is thought to be involved. In animals, the mesoprefrontal dopaminergic system is particularly vulnerable to stress, and chronic stress induces working memory impairment. However, the relation between the working memory impairment and altered dopaminergic activity in chronically stressed rats is unclear. Furthermore, the… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 64 references

Supranormal stimulation of D1 dopamine receptors in the rodent prefrontal cortex impairs spatial working memory performance.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 1997
View 14 Excerpts
Highly Influenced

Suppression of glucocorticoid secretion and antipsychotic drugs have similar effects on the mesolimbic dopaminergic transmission.

Proceedings of the National Academy of Sciences of the United States of America • 1996
View 6 Excerpts
Highly Influenced

Ljungdal A (1974) The origin of DA nerve terminals in limbic and frontal cortex. Evidence for mesocortical neurons

K Fluxe, T Hökfelt, O Johansson, G Jonnson, P Lidbrink
Brain Res • 1974
View 5 Excerpts
Highly Influenced

The origin of DA nerve terminals in limbic and frontal cortex . Evidence for mesocortical neurons

K Fluxe, T Hökfelt, +3 authors A Ljungdal
Brain Res • 1974
View 5 Excerpts
Highly Influenced

Dopamine receptor agonists: selectivity and dopamine D1 receptor efficacy.

European journal of pharmacology • 1990
View 2 Excerpts
Highly Influenced

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