Chronic stress induces adrenal hyperplasia and hypertrophy in a subregion-specific manner.

@article{UlrichLai2006ChronicSI,
  title={Chronic stress induces adrenal hyperplasia and hypertrophy in a subregion-specific manner.},
  author={Yvonne M. Ulrich-Lai and Helmer F. Figueiredo and Michelle M. Ostrander and Dennis C. Choi and William C. Engeland and James P Herman},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2006},
  volume={291 5},
  pages={E965-73}
}
The adrenal gland is an essential stress-responsive organ that is part of both the hypothalamic-pituitary-adrenal axis and the sympatho-adrenomedullary system. Chronic stress exposure commonly increases adrenal weight, but it is not known to what extent this growth is due to cellular hyperplasia or hypertrophy and whether it is subregion specific. Moreover, it is not clear whether increased production of adrenal glucocorticoid after chronic stress is due to increased sensitivity to… CONTINUE READING