Chronic stress-induced neurotransmitter plasticity in the PVN.

  title={Chronic stress-induced neurotransmitter plasticity in the PVN.},
  author={Jonathan N. Flak and Michelle M. Ostrander and Jeffrey G. Tasker and James P Herman},
  journal={The Journal of comparative neurology},
  volume={517 2},
Chronic stress precipitates pronounced enhancement of central stress excitability, marked by sensitization of hypothalamic-pituitary-adrenocortical (HPA) axis responses and increased adrenocorticotropic hormone (ACTH) secretagogue biosynthesis in the paraventricular nucleus of the hypothalamus (PVN). Chronic stress-induced enhancement of HPA axis excitability predicts increased excitatory and/or decreased inhibitory innervation of the parvocellular PVN. We tested this hypothesis by evaluating… CONTINUE READING
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