Chronic stress in mice remodels lymph vasculature to promote tumour cell dissemination.

  title={Chronic stress in mice remodels lymph vasculature to promote tumour cell dissemination.},
  author={Caroline P. Le and Cameron J Nowell and Corina Kim-Fuchs and Edoardo Botteri and Jonathan G. Hiller and Hilmy M Ismail and Matthew A. Pimentel and Ming G Chai and Tara Karnezis and Nicole Rotmensz and Giuseppe Renne and Sara Gandini and Colin W. Pouton and Davide Ferrari and Andreas M{\"o}ller and Steven A Stacker and Erica K. Sloan},
  journal={Nature communications},
Chronic stress induces signalling from the sympathetic nervous system (SNS) and drives cancer progression, although the pathways of tumour cell dissemination are unclear. Here we show that chronic stress restructures lymphatic networks within and around tumours to provide pathways for tumour cell escape. We show that VEGFC derived from tumour cells is required for stress to induce lymphatic remodelling and that this depends on COX2 inflammatory signalling from macrophages. Pharmacological… CONTINUE READING


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