Chronic stress in elderly carers of dementia patients and antibody response to influenza vaccination

@article{Vedhara1999ChronicSI,
  title={Chronic stress in elderly carers of dementia patients and antibody response to influenza vaccination},
  author={Kav Vedhara and Nigel KM Cox and G. K. Wilcock and Paula Perks and Nola M Shanks},
  journal={The Lancet},
  year={1999},
  volume={353},
  pages={627-631}
}
BACKGROUND There are many reports of psychological morbidity in spousal carers of patients with dementia. [...] Key ResultsEight (16%) of 50 carers and 26 (39%) of 67 controls had a four-fold increase in at least one of the IgG titres (p=0.007). There was an inverse relation between AUC cortisol and IgG antibody titre to the Nanchang strain that was significant on day 14 (r=-0.216, p=0.039). INTERPRETATION Elderly carers of spouses with dementia have increased activation of the hypothalamic-pituitary-adrenal… Expand Abstract

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