Chronic stress enhanced fear memories are associated with increased amygdala zif268 mRNA expression and are resistant to reconsolidation.

@article{Hoffman2015ChronicSE,
  title={Chronic stress enhanced fear memories are associated with increased amygdala zif268 mRNA expression and are resistant to reconsolidation.},
  author={Ann N Hoffman and Alejandro Parga and Pooja R Paode and Lucas R Watterson and Ella M. Nikulina and Ronald P. Hammer and Cheryl D. Conrad},
  journal={Neurobiology of learning and memory},
  year={2015},
  volume={120},
  pages={61-8}
}
The chronically stressed brain may present a vulnerability to develop maladaptive fear-related behaviors in response to a traumatic event. In rodents, chronic stress leads to amygdala hyperresponsivity and dendritic hypertrophy and produces a post traumatic stress disorder (PTSD)-like phenotype that includes exaggerated fear learning following Pavlovian fear conditioning and resistance to extinction. It is unknown whether chronic stress-induced enhanced fear memories are vulnerable to… CONTINUE READING
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