Chronic stress disrupts fear extinction and enhances amygdala and hippocampal Fos expression in an animal model of post-traumatic stress disorder

@article{Hoffman2014ChronicSD,
  title={Chronic stress disrupts fear extinction and enhances amygdala and hippocampal Fos expression in an animal model of post-traumatic stress disorder},
  author={Ann N. Hoffman and Nickolaus G. Lorson and Federico Sanabria and Michael Foster Olive and Cheryl D. Conrad},
  journal={Neurobiology of Learning and Memory},
  year={2014},
  volume={112},
  pages={139-147}
}
Chronic stress may impose a vulnerability to develop maladaptive fear-related behaviors after a traumatic event. Whereas previous work found that chronic stress impairs the acquisition and recall of extinguished fear, it is unknown how chronic stress impacts nonassociative fear, such as in the absence of the conditioned stimulus (CS) or in a novel context. Male rats were subjected to chronic stress (STR; wire mesh restraint 6 h/d/21d) or undisturbed (CON), then tested on fear acquisition (3… CONTINUE READING
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