Chronic stress augments the long-term and acute effects of methamphetamine

@article{Matuszewich2004ChronicSA,
  title={Chronic stress augments the long-term and acute effects of methamphetamine},
  author={Leslie Matuszewich and Bryan K. Yamamoto},
  journal={Neuroscience},
  year={2004},
  volume={124},
  pages={637-646}
}
There is growing evidence that exposure to stress alters the acute effects of abused drugs on the CNS. However, it is not known whether stress augments the longer-term neurotoxic effects of psychostimulant drugs, such as methamphetamine. Methamphetamine at high doses decreases forebrain dopamine concentrations. The current study tested the hypothesis that 10 days of unpredictable stress augmented striatal dopamine depletions 7 days following four injections of either 7.5 or 10 mg/kg… CONTINUE READING
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