Chronic stress attenuates glucocorticoid negative feedback: involvement of the prefrontal cortex and hippocampus.

@article{Mizoguchi2003ChronicSA,
  title={Chronic stress attenuates glucocorticoid negative feedback: involvement of the prefrontal cortex and hippocampus.},
  author={Kazushige Mizoguchi and Atsushi Ishige and Masaki Aburada and Takeshi Tabira},
  journal={Neuroscience},
  year={2003},
  volume={119 3},
  pages={887-97}
}
Disruption of the glucocorticoid negative feedback system is observed in approximate one half of human depressives, and a similar condition is induced in animals by chronic stress. This disruption is thought to involve down-regulation of glucocorticoid receptors (GRs) in the feedback sites of the brain. However, the responsible site of the brain has not been well elucidated. Here we examined the effects of chronic stress induced by water immersion and restraint (2 h/day) for 4 weeks followed by… CONTINUE READING

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