Chronic stress and susceptibility to skin cancer.

  title={Chronic stress and susceptibility to skin cancer.},
  author={Alison N. Saul and Tatiana M. Oberyszyn and Christine Daugherty and Donna Frances Kusewitt and Susie Jones and Scott Jewell and William B. Malarkey and Amy G Lehman and Stanley Lemeshow and Firdaus S. Dhabhar},
  journal={Journal of the National Cancer Institute},
  volume={97 23},
BACKGROUND Studies have shown that chronic stress or UV radiation independently suppress immunity. Given their increasing prevalence, it is important to understand whether and how chronic stress and UV radiation may act together to increase susceptibility to disease. Therefore, we investigated potential mediators of a stress-induced increase in emergence and progression of UV-induced squamous cell carcinoma. METHODS SKH1 mice susceptible to UV-induced tumors were unexposed (naïve, n = 4) or… CONTINUE READING
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