Chronic stress accelerates pancreatic cancer growth and invasion: A critical role for beta-adrenergic signaling in the pancreatic microenvironment

@article{KimFuchs2014ChronicSA,
  title={Chronic stress accelerates pancreatic cancer growth and invasion: A critical role for beta-adrenergic signaling in the pancreatic microenvironment},
  author={Corina Kim-Fuchs and Caroline Phuong Le and Matthew A. Pimentel and David M Shackleford and Erica K. Sloan},
  journal={Brain, Behavior, and Immunity},
  year={2014},
  volume={40},
  pages={40-47}
}
Pancreatic cancer cells intimately interact with a complex microenvironment that influences pancreatic cancer progression. The pancreas is innervated by fibers of the sympathetic nervous system (SNS) and pancreatic cancer cells have receptors for SNS neurotransmitters which suggests that pancreatic cancer may be sensitive to neural signaling. In vitro and non-orthotopic in vivo studies showed that neural signaling modulates tumour cell behavior. However the effect of SNS signaling on tumor… CONTINUE READING
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