Chronic sodium nitrite therapy augments ischemia-induced angiogenesis and arteriogenesis.

@article{Kumar2008ChronicSN,
  title={Chronic sodium nitrite therapy augments ischemia-induced angiogenesis and arteriogenesis.},
  author={Dr.M.Suresh Kumar and Biostatistics Branch and Christopher B Pattillo and Jay J. Hood and Stephen J. Thoma and Stephen R. Simpson and Sandra A. Illum and Neeraj Arora and John H. Chidlow and William C. Langston and Xinjun Teng and David Joseph Lefer and Rakesh P Patel and Christopher G. Kevil},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 21},
  pages={
          7540-5
        }
}
Chronic tissue ischemia due to defective vascular perfusion is a hallmark feature of peripheral artery disease for which minimal therapeutic options exist. We have reported that sodium nitrite therapy exerts cytoprotective effects against acute ischemia/reperfusion injury in both heart and liver, consistent with the model of bioactive NO formation from nitrite during ischemic stress. Here, we test the hypothesis that chronic sodium nitrite therapy can selectively augment angiogenic activity and… CONTINUE READING

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